End of Life Care for people with Liver Disease
Partnership with Marie Curie and the Royal Free Hospital, London. The research was completed in 2017 and the report is available here: https://bmjopen.bmj.com/content/7/8/e016887.full?ijkey=PGkAXwp8zrd7zyj&keytype=ref
Survey of Liver Services in Scotland
Alastair MacGilchrist – Royal Infirmary of Edinburgh
Survey commissioned by the British Liver Trust and the Scottish Society of Gastroenterology on the provision of secondary care services for patients with liver disease in Scotland 2013.
Report – Survey of Liver Services in Scotland
LOCATE – Early Detection Model
Dr Nick Sheron – University of Southampton
This is an ongoing project of patient based research to implement screening to increase the earlier detection and diagnosis of liver disease. The desired outcome is an effective detection model that can be used nationally and adapted for international implementation.
Development of Visual Aids to Assist Discussions with Patients on Treatment Options
Mr Kurinchi Gurusamy – Royal Free Hospital, London
Ongoing study looking at the development of visual aids to improve shared decision making with patients on their condition and treatment options.
Developing Effective Liver Function Tests (LFTs)
Led by British Society of Gastroenterology (BSG)
Study on the effectiveness and knowledge of outcomes of LFTs in Primary Care and GP surgeries. This was launched in December 2017, here is the report: https://www.bsg.org.uk/resource/new-guidelines-on-the-management-of-abnormal-liver-blood-tests—press-release.html
People’s Experiences of Liver Transplant Services
Ongoing study led by the Picker Institute
This is an ongoing study with funding and involvement by the British Liver Trust for the British Liver Transplant Group (BLTG) to develop evidence on the views, preferences, and experiences of those involved in liver transplant services, namely; a) Patients (particularly adults) who have received liver transplants; b) NHS staff involved in the provision of transplant services.
Currently, little is known about patients view as strengths and weaknesses of the current service model for liver transplant provision – or about how well this model meets their preferences. The study will collect the views and preferences of patients. Ultimately, this could provide evidence to inform and influence a potential review of how transplant services are organised.
Epidemiology of Liver Disease in Tayside Study
Dr J F Dillon – Ninewells Hospital and Medical School, Dundee
Impact and Burden of Liver Disease in the UK
Dr P Roderick – University of Southampton, School of Medicine
(Funded jointly with the Foundation for Liver Research)
Systematic Review of the Prevalence of Mildly Abnormal Liver Function Tests and Associated Health Outcomes
Sven Radcke, John F Dillon and Aja L Murray – British Liver Trust, University of Edinburgh, University of Dundee
To read the full article visit the European Journal of Gastroenterology
Abstract Results Table 1 Results Table 2
James Lind Alliance Alcohol-Related Liver Disease Priority Setting Partnership (PSP)
The British Liver Trust played a key part in this exercise that sought to agree key research priorities. Data was collected through a survey asking patients, carers and health professionals for their unanswered questions around the diagnosis, treatment and care of alcohol-related liver disease. Over 230 responses were received from across the UK, and the top 25 questions were then taken to the JLA Alcohol-Related Liver Disease PSP workshop in September, where health professionals, patients and carers worked collaboratively to reach the final Top 10.
General Public Awareness Survey
The British Liver Trust commissioned survey from market research company ComRes to find out the perception of liver disease among adults in the UK.
Specific Liver conditions
Pathogenesis of Primary Biliary Cirrhosis
Dr J Neuberger – University Hospital Birmingham
Final research article
The Molecular Basis of Mucosal T Cell Homing to the Liver in Primary Sclerosing Cholangitis
Professor David Adams – University of Birmingham
Molecular Action of New Therapies in Obstetric Cholestasis
Professor Catherine Williamson – Imperial College, London
This is an ongoing project. Professor Williamson is researching potential safe treatments in pregnancy to protect the unborn child from bile induced damage as happens in Obstetric Cholestasis. This project has been extended for additional clinical trials on two other potential drug therapies.
Development, Validation and Evaluation of a Disease Specific Quality of Life (QoL) Tool for Primary Sclerosing Cholangitis (PSC)
Lead consultant Dr Douglas Thorburn – Royal Free Hospital, London
There is currently no specific tool to measure quality of life for PSC patients, NICE relies on evidence from QoL and economic measurements, to appraise new potential medicines and treatments; it is vital therefore to develop high quality validated tools to help ensure any effective PSC therapies have the best chance of becoming available to patients. This project is at ethics stage and will include a patient questionnaire and literature review before reporting again in 12-18 months’ time.
Project funded by a supporter legacy.
European Study on New Treatments for Non Alcohol Related Fatty Liver Disease (NAFLD)
Led by Dr Emmanouil Tsochatzis – Royal Free Hospital, London
Ongoing research study aiming to ascertain if the administration of simvastatin or rifaximin, alone or in combination, can reduce the incidence of hepatic decompensation or mortality in patients with compensated cirrhosis and clinically significant portal hypertension.
New Therapy against Wilson’s Disease
Led by Professor Aftab Ala, Consultant Hepatologist, Royal Surrey County Hospital
This is an ongoing research project in which British Liver Trust is helping recruit patients for a new research study to evaluate the efficacy and safety of a new therapy against Wilson’s disease. Information on eligibility for the trial can be found on our page here. Additional information is available here or by contacting Professor Aftab Ala, Consultant Hepatologist, Royal Surrey County Hospital NHS Foundation Trust, by email to: firstname.lastname@example.org
Antigen Presentation in HBV Infection
Miss S Shanmuganathan – St Mary’s Hospital, London
Creation of Hepatitis B (HBV) Research Network and Biobank
Led by Medical Research Council
Ongoing project to create an equivalent Biobank for Hepatitis B research as currently already exists for Hepatitis C.