Liver Transplantation

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A liver transplant is an operation where your diseased liver is removed and replaced with a healthy donor human liver.

Although liver transplants are now quite common, the operation is not undertaken lightly.  It is a major operation and the body will always see the ‘new’ liver as a foreign agent and will try to destroy it. 

You may need a liver transplant if your liver is damaged to the point where it is unable to repair itself and is likely to fail completely.

Your doctor may advise you to have a transplant when it is thought this will either dramatically improve your quality of life or that, without a transplant, you will die.

The main causes of severe liver damage that lead to people needing a transplant are:
● cirrhosis
● hepatitis
● metabolic conditions (problems with the physical and chemical processes that take place inside your liver to keep you alive)
● paracetamol poisoning.

By the time you discover you need a transplant your liver might begin to fail and your quality of life may be very poor. You may have experienced the following symptoms:
● loss of appetite
● generally feeling unwell and being tired all the time
● feeling sick and being sick
● very itchy skin
● loss of weight and muscle wasting 

● enlarged and tender liver (you may feel verymtender below your right ribs)

● increased sensitivity to alcohol and drugs (medical and recreational)
● yellowing of the skin and whites of the eyes (jaundice)
● swelling of the lower abdomen, or tummy (ascites), or the legs (peripheral oedema)
● fever with high temperatures and shivers, often caused by an infection
● vomiting blood
● dark black tarry stools (faeces) or pale stools, associated with cholestatic disease
● periods of mental confusion.
If your transplant is successful, not only should
these problems clear up but you will have a longer
life expectancy.

When a suitable donor is found the hospital will contact you. This can happen at any time, day or night. You will either be offered transport to the hospital or you can choose to make your own
way there.

You must stop eating and drinking immediately as soon as you receive the phone call. If you have diabetes, tell your transplant coordinator.

When you arrive at the hospital you will be taken to a ward where your doctor will go through your medical history and you will have a chest X-ray and an ECG. You will be required to wash with an antiseptic soap in readiness for the operation.An anaesthetist will give you an injection, called a pre-med, to help you relax. A small needle, called a canula, will be put into the back of your hand or your wrist. This will help the anaesthetist give you the drugs for the operation. You will then be taken to the operating theatre where any friends or relatives will have to leave you. At this point you will be connected to several machines to measure
your heart rhythm and blood pressure and the anaesthetist will put you to sleep.

Tests before transplant

Before having a liver transplant you will need to have a number of tests to help the doctors decide whether this operation is the best treatment for you. You may already be familiar with some of these tests from your diagnosis phase. You may also have to repeat a number of tests during your assessment for a transplant.

This period of assessment, which lasts around five days, can be a difficult time but it is important that the doctors see that you are fit enough to have the operation. It is also important for the doctors to be sure that you are fully aware of the commitment that you need to make to your own healthcare after the operation.

The testing period is also a time that can be used to fully understand the commitment to your own healthcare you’ll need to make after the operation, such as commiting to giving up alcohol for the rest of your life.

Sometimes the tests will show that you may have other medical conditions which will need to be treated before a transplant can take place.

You may find it helpful to view the following workbook developed by Leeds Transplant team: Alcohol and the liver workbook

During the assessment period you will probably be feeling very unwell. Being poked and prodded is probably the last thing you want. The doctors are aware of this and understand that you will have some bad days when you are not feeling your best. It is important to talk honestly about your feelings and concerns with the medical staff.

After all the tests have been done, the transplant team will discuss whether a transplant is the most suitable course of treatment for you. If the transplant team do not think that a transplant is the best option at this stage, you will be given another course of treatment.

During your assessment many different healthcare professionals may ask very similar questions. While this may seem repetitive and boring, you must remember that it is very important that you answer all the questions as truthfully and fully as possible. These interviews will help the transplant team decide whether you are a suitable candidate for a transplant.

Your doctors need to consider both your physical and your mental health because a liver transplant is major surgery that you need to be able to cope both physically and mentally.

Blood tests
Blood tests are used to understand your general health and find out if there are any factors which can cause problems in people with transplants. People with cirrhosis have a much higher chance of getting liver cancer (hepatocellular carcinoma, or HCC), therefore your test will also check for cancers.

Chest X-ray
A chest X-ray uses radiation to form a picture of your heart and lungs so that your doctors can tell whether these organs are working well.

Lung function
Lung function tests are used to check how much air is moving in and out of your lungs.

Blood oxygen test
In order to measure the amount of oxygen in your blood, doctors will take a small amount of blood from a vein in your wrist.

Electrocardiogram (ECG)
An electrocardiogram, commonly called an ECG, is used to find out how your heart is working. Leads are attached by pads to your chest, arms and legs and linked to a machine which measures the electrical activity in the heart.

Echocardiogram and stress echo 
An echocardiogram is another heart test and is used to assess the size of your heart and its ability to pump blood properly. The procedure is similar to ultrasound where a probe, like a microphone, is moved by hand over your heart area to send sound waves through your skin. It will record any reflected sound waves and send them to a computer which is able to process the waves as pictures. In addition to this procedure you will be required to perform a physical exercise, such as running or walking on a treadmill, so that doctors can compare your heart action following activity.

Coronary angiography 
During a coronary angiography a dye will be injected into your arteries and an X-ray will be taken. This helps doctors understand how healthy your arteries are and whether there are any problems that could make the transplant too risky to carry out. This test is only required in selected cases where there are risk factors such as coronary disease, age (over 60), smoking and hypertension (high blood pressure).

Kidney function tests 
Problems with the kidneys are a common side effect of liver failure. Tests for kidney function include blood and urine tests.

Ultrasound scan
Ultrasound is the same technology used to confirm all is well in pregnancy. Gel will be applied to your skin, which may feel slightly cold. A probe will be moved across your skin to send sound waves into the liver area. The reflected sound waves, or echoes, are picked up through the probe and used to build a screen image of the liver’s condition. This painless test is often used to check the condition of the bile ducts.

CT scan (computerised tomography) 
A CT scan uses special X-ray equipment to give doctors a detailed picture of your internal organs and body tissue, particularly the chest and abdomen. To help with this you will be given a dye which you might either swallow or have injected into your veins. You will then lie on a bed which will be passed through a scanner.

MRI (magnetic resonance imaging) 
An MRI scan uses magnetic fields to create a computerised image of the body that is even more detailed than a CT scan. As with a CT scan, you will be asked to lie on a bed which will be passed through a scanner.

Liver biopsy 
A liver biopsy is a process where a tiny piece of the liver is taken for study. A fine hollow needle is passed through the skin into the liver and a small sample is withdrawn. The test is usually done under local anaesthetic and may mean an overnight stay in hospital, although some people may be allowed home later the same day. As the test can be uncomfortable with a small risk of internal bleeding or bile leakage, a stay in bed of at least six to eight hours is required.

During an endoscopy a very thin tube with a tiny camera is lowered down your throat and into your stomach. This is usually done under local anaesthetic. Endoscopy is used to find out whether the tiny veins (varices) in your stomach and gut are damaged or bleeding.

After the transplant and leaving hospital

Once the operation is complete, you will be taken to intensive care. When you wake up you will:

  • have a tube in your throat and are attached to a ventilator to help you breathe
  • are attached to machines which help your doctors monitor your condition
  • have a tube in your nose.

When you start breathing normally the tube in your windpipe will be removed and you will be given oxygen through a face mask. You might have a bit of a sore throat at this point and the nurses will then take you through a few breathing exercises. You will also be given several pain relief injections.

Over the next few days you will continue to be given pain relief. You may be able to control this yourself via a PCA (pain-controlled analgesia or ‘Pica’) device. You will have routine blood tests and chest X-rays and you will also be given antibiotics.

Your transplant team will take you through what you can expect when you get home. Once you are at home you should be contacted by your transplant coordinator who will see how you are getting on.

To prevent your body rejecting a new healthy liver you will need to take a number of medicines, including strong drugs known as immunosuppressants.

Go through each medicine carefully with your healthcare team as some medications react badly with others, as well as certain foods. If you have any questions talk with your doctor or pharmacist.

Some of the drugs that you will be given can have side effects, including:

  • kidney damage
  • high blood pressure
  • high cholesterol
  • obesity

After about two days you will be moved onto a ward. Over the next few days you will find that you can move about more and will be encouraged to do so.

You can begin to eat between one and five days after the operation, with advice from a dietician.

It is quite common to feel a bit low after the operation. This is normal and is caused by the stress of having a major operation and the drugs you are taking. Other side effects of the drugs include vivid dreams and nightmares, with some people experiencing waking hallucinations.

If you are worried about the side effects of the medicine talk to your GP, the hospital pharmacist or your liver team.

You may be given regular booster vaccinations against disease. If so, these will never be in the form of a live vaccine and will not be started for at least six months after your transplant.

If you are planning to travel to another country talk to your doctor. There are two things you must think about:

  • It is vital that you do not have a live vaccination as this will react very badly with the drugs (immunosuppressants) you are taking to stop your new liver being rejected.
  • Always make sure that you have enough medicines to last you for the entire trip, with a few extra to cover any delays or emergencies.


When you get home it is normal to feel anxious and disorientated. You may also feel very tired. This is normal. If you have any worries contact the transplant team. In emergencies contact the transplant coordinator. Bear in mind the following points.

  • Exercise – the hospital physiotherapist will give you a gentle exercise plan. This will help your recovery and should be built up slowly. Avoid any contact sports or swimming for six months.
  • Driving – because you have had an operation in the abdominal area you should avoid driving for two months after the operation.
  • Blurred vision – this is quite normal for the first few months after the transplant and should get better after a time.
  • Telling people about your transplant – you must make sure that other medical professionals, such as a doctor, dentist or optician, know about your transplant before they give any treatment.
  • Work and money – getting back to work will depend on whether you have any complications and your general rate of recovery. Some people, although not the majority, can return to work around three months after the transplant. The hospital can arrange for you to see a social worker to help you if you face financial hardship because of time spent off work.
  • Infections – because of the strong drugs (immunosuppressants) you have to take after
    the operation you will be far more at risk of infections. It is important that you do not smoke afterwards and that you maintain good personal and domestic hygiene. People who have infections should not visit you and you should stay away from large crowds or gatherings.
  • Skin cancer – after the transplant you will be at far higher risk of skin cancer. If you go on holiday to sunny spots abroad or are just spending more time outdoors you should always protect yourself from the sun. Keep an eye out for any changes in your skin and in any moles or spots.
  • Sex – you can resume sex as soon as you feel ready. Men can find that it can take a couple of months for everything to work normally again. If you have any concerns you should discuss them with your doctor. Both women and men have a higher risk of contracting sexually transmitted diseases (STDs) so take extra care and practice safe sex.
  • Menstruation – after the transplant women will find that their menstrual cycle is disrupted, returning to normal in two to eight months. Some medications stop periods happening but care should be taken as this does not mean you cannot get pregnant.
  • Pregnancy – women hoping to get pregnant should get advice from their doctor. In general you should wait for 12 months after the operation before trying to get pregnant.
  • Pets – it is not a good idea to keep exotic pets or birds after a transplant as the risk of picking up disease is higher. Always wear gloves if you have to come into contact with any of your pet’s body fluids, such as saliva and faeces, and wash your hands afterwards.

Download publication

Download current edition:  Liver Transplantation publication LT/03/19  

Special thanks to: Dr Audrey Dillon, consultant hepatologist, Leeds Teaching Hospitals NHS Trust; Mr Parthi Srinivasan, consultant surgeon and liver transplant specialist, King’s College Hospital NHS Foundation Trust; Dr Abid Suddle, consultant hepatologist and liver transplant specialist, King’s College Hospital NHS Foundation Trust; Lay reviewers Jane Cooke and Lucy Anderson Jones

FAQs and Further Information

Frequently Asked Questions

As now, your family doctor or referring consultant will decide if a transplant will be of benefit to you. Priority is always given to those patients on the ‘super urgent’ list (this list is for very sick patients expected to die within days without a liver transplant).

Most people who undergo liver transplant have a chronic liver disease which is limiting their life expectancy. Without a transplant they may only have a few years to live. Other patients have a very poor quality of life due to the symptoms of liver disease. For them the aim of the transplant is to restore their health and improve their quality of life. In this situation, liver transplant is offered only if all other forms of treatment have failed.*

Before the new scheme was introduced, patients with a liver disease were assessed on their need for a liver transplant based on their UKELD score (United Kingdom Model for End Stage Liver Disease). Clinicians calculated this score by looking at 4 different patient characteristics from the liver patient.

The new scheme is designed to be more in-depth and takes into account 7 characteristics from the donor; these donor characteristics are then ‘matched’ with 21 patient characteristics. The patient with the best match will be shown at the top of the list and will have the highest transplant benefit score.

The TBS predicts which patient will benefit the most from the transplanted liver – who will live the longest with the transplant, but also who can survive the longest on the list without receiving a transplant and is, therefore, able to safely wait a while longer before being offered a liver transplant.

Yes – those livers from brain stem dead donors have less damage than a liver from a donor following circulatory death and this is due to how the liver is retrieved; and obviously a liver from a young and previously fit donor with an isolated head injury will be a better liver than one retrieved from an elderly donor who smokes and who has diabetes.

It’s not possible to predict accurately how long you will need to wait for a transplant. Each case is different and the new scheme is designed to ensure that any liver that becomes available is matched to the best recipient depending on the Transplant Benefit Score. As stated above, priority is always given to those patients on the ‘super urgent’ list (this list is for very sick patients expected to die within days without a liver transplant).

Yes, waiting time accrued on the current list will be carried over into the new scheme.

No, the new scheme is a national offer scheme. All patient data is held centrally and each time a liver becomes available the system generates a ‘matching run’. The patient with the best match for the available liver will be offered the organ – regardless of location.

The change to the new scheme will be seamless for all patients; your transplant centre has already supplied the information needed to work out your TBS for any liver being offered for transplantation. Your centre will update your information any time there is a change in your circumstances, but must also do so every three months. Therefore, it is very important that you attend your clinics on a regular basis, so that your data is current and accurately reflects your condition.

The computer will produce a matching run for variant syndrome patients with a frequency based on the statistical incidence of patients registered as variant syndrome patients. This currently stands at 10% of patients on the transplant waiting list. Therefore, on average, around 10 in every 100 matching runs will be for variant syndrome patients. These recipients will be ranked in the offering sequence according to how long they have been registered on the waiting list.

The way the system works is not centre driven. The Transplant Benefit Score uses 7 characteristics from the donor; these donor characteristics are then ‘matched’ with 21 patient characteristics. The patient with the best match will be shown at the top of the list and will have the highest transplant benefit score, regardless of geographical location.

Organ donation is confidential, so while you may be given some details about the person donating their organs you will not be given any identifiable information and you will not be told who they are. You may have different feelings about your transplant, from relief to fear. You may well feel sad for the person who has died and for their grieving family. It is important to remember that organ donation is something positive that can come out of what is otherwise a tragic event: this can bring a lot of comfort to the bereaved family.

Whatever your thoughts are now, you may feel differently after your transplant. After your transplant you may wish to write to the donor’s family. There is no rush to do this; in many ways it is better to wait until you are out of hospital and well on the road to recovery before you write. This also allows the family to come to terms with their loss and to grieve.

For more information please see:

NHS Blood and Transplant website

Trust news item on New Liver Offering Scheme


  1. UKELD a scoring system used to predict prognosis for patients with a liver disease, it takes into account INR, (international normalised ratio), Serum Creatinine, Serum Bilirubin and Serum Sodium.
  2. Donor characteristics include age, cause of death, BMI, diabetes, donor type, blood group and split liver criteria.
  3. Patient characteristics include age, gender, Hepatitis C, disease group, creatinine, bilirubin, INR, Sodium, Potassium, Albumin, renal support, inpatient status, previous abdominal surgery, encephalopathy, ascites, time on waiting list, diabetes, maximum AFP level, maximum tumour size, two tumours, three or more tumours those patients with variant syndrome disease – this group of patients will now have a better prospect of receiving a transplant match.

Further Information

The National Liver Offering Scheme was introduced by NHS Blood and Transplant (NHSBT) in March 2018. It is a way of matching donor livers to patients on the liver transplant waiting list on a national basis rather by region. The scheme also introduces a new scoring system called the Transplant Benefit Score (TBS). See our Frequently Asked Questions page for more information.

Please visit the support section of our website for information on Support groups in your area or visit our Useful Links section for other organisations who may be able to offer information and support.

Further information

The Haemochromatosis Society (Haemochromatosis UK)
PO Box 6356
CV21 9PA
Office: 03030 40110
Advice Line: 03030 401102
Promotes awareness among the health professions, patients and their families, the general public and policy makers.It encourages and supports research, publishes a quarterly newsletter and provides resource material for the medical professions.

Irish Haemochromatosis Association 
The Carmichael Centre
North Brunswick Street
Dublin 7
Provides support and information for people with haemochromatosis and related disorders in Ireland. It produces a newsletter, brochures and other media to provide information and raise awareness of haemochromatosis.

Find Support

Please visit the support section of our website for information on Support groups in your area.