Autoimmune Hepatitis: symptoms & diagnosis
What are the symptoms of Autoimmune Hepatitis?
Symptoms of Autoimmune Hepatitis (AIH) can range from none to mild to severe. It is common to have no symptoms at the beginning. Some people may not have symptoms when they are diagnosed but they may develop them later. Others develop symptoms quickly over a few days (acute hepatitis – an illness that develops quickly).
When symptoms do start to appear, they often start over weeks or months. The symptoms are often nonspecific and have many possible causes so your doctor may not immediately attribute your symptoms to liver disease.
How is autoimmune hepatitis diagnosed?
As many people have either no symptoms or symptoms that are common for many other conditions, in the early stages of Autoimmune Hepatitis it is often diagnosed by a medical professional either when you have had routine tests, or tests for an unrelated condition.
For those who have symptoms, diagnosis is usually made though a mixture of taking a careful medical history, performing a physical examination, a range of blood tests and a liver biopsy. A diagnosis of Autoimmune Hepatitis is usually made by looking at your test results and ruling out other causes of liver disease such as fatty liver disease or viral hepatitis.
Treatment for Autoimmune Hepatitis
Once you have been diagnosed with Autoimmune Hepatitis, treatment is almost always needed. The type of treatment used is called immunosuppression (reducing how active your immune system is).This is done by using a combination of medications.
The main goal of treatment is to stop the liver inflammation by suppressing your immune system (make it less active) but this can also reduce the ability of your immune system to fight infection. Reducing the liver inflammation will improve your symptoms, improve your liver tests, reduce the degree of scarring and help prevent long term liver damage and liver failure. Once treatment has started it is long-term, for at least two years and it is usually lifelong. It may be possible to stop treatment in a few people with AIH, however this is not without risk as a relapse (becoming ill again) can occur and you may need further treatment.
Azathioprine
Azathioprine is an immunosuppressant (a medication which reduces how active your immune system is). It is used to treat Autoimmune Hepatitis and other chronic inflammatory and autoimmune conditions. It is also used to help stop the body fighting (rejecting) a new organ after a transplant.
Azathioprine works by suppressing your immune system, similarly to prednisolone, thereby reducing inflammation and the symptoms it causes. Your doctor will prescribe a dose (tell you how much) of the medication for you to take; this will depend on your weight and condition. The tablets should be taken with plenty of water, after eating a meal or with a snack, to help stop you feeling sick.
Other medication to treat AIH
The inflammation can be controlled well in most people using a combination of steroids and azathioprine. Indeed in some people, the steroids can be stopped and azathioprine is enough to control the disease. However, some people cannot tolerate these drugs or they are not effective enough. There are other drugs that liver doctors will use but these too have side-effects.
Further Information
Looking after yourself
- Alcohol
Alcohol is a toxin processed by your liver and, as a result, it can be dangerous for anyone with liver problems. Check with your doctor whether it is safe for you to drink any alcohol and, if so, how much.Smoking
Smoking is dangerous to everyone’s health. Smoking can increase the severity of liver damage.People with liver disease are more vulnerable to infection and to poor health overall, so smoking or exposure to passive smoking is not advisable. If you smoke, speak to your doctor about what help is available with cutting down and giving up.
Diet and exercise
Being overweight or obese can affect the progression, or treatment of your liver condition. If you have a liver condition, there may be some special considerations you need to make in your diet to stay nutritionally well and to help manage your condition. Some of these are specific to certain liver diseases, others relate to how advanced your liver condition is (see our ‘Diet and liver disease’ section).It is important that while you are taking prednisolone you avoid liquorice or products containing liquorice as it can interact with your treatment.
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