Interpreting Abnormal Liver Blood Tests or LFTs – Guidelines
These guidelines on the management of abnormal liver blood tests have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG with input from a wide number of groups including the RCGP and the British Liver Trust.
They deal specifically with the management of abnormal liver blood tests in adults in both primary and secondary care under the following subheadings:
- What constitutes an abnormal liver blood test?
- What constitutes a standard liver blood test panel?
- When should liver blood tests be checked?
- Does the extent and duration of abnormal liver blood tests determine subsequent investigation?
- Response to abnormal liver blood tests.
The guidelines
Patient information factsheets
Download and print out copies of our patient-friendly factsheets on:
Alcohol-related liver disease (ARLD)
Alcohol-related liver disease (ARLD) is liver damage that is caused by drinking too much alcohol. There are several stages of ARLD ranging from mild to severe. This factsheet sets out how alcohol damages the liver, how patients can prevent the damage from getting worse, what happens following an ARLD diagnosis and links to further support.
Download here >Non-alcohol related liver disease (NAFLD)
Non-alcohol related liver disease (NAFLD) is caused by a build up of fat in the liver. It is estimated that one in three people in the UK have NAFLD. This factsheet sets out how alcohol damages the liver, how patients can prevent the damage from getting worse, what happens following a NAFLD and links to further support.
Download here >RCGP liver disease toolkit
The aims of the British Liver Trust/RCGP Liver Clinical Priority Project are to raise awareness of liver disease as an increasingly important cause of morbidity and mortality in the UK and to provide resources to support its optimal management in primary care.
National guidance
This section provides links to national guidance and resources focusing on the management of liver disease
- NICE NG49 non-alcoholic fatty liver disease guidance (2016)
- NICE NG50 cirrhosis in over 16s guidance (2016)
- BSG LFT guidance 2017
- NICE PH43 hepatitis B and C testing guidance (2013)
- NICE CG165 hepatitis B (chronic): diagnosis and management (2013)
- SIGN 133 management of hepatitis C guidance (2013)
- SIGN 115 management of obesity guidance (2013)
- NICE CG189: obesity guidance (2014)
- NICE CG115: Alcohol-use disorders: diagnosis, assessment and management of harmful drinking and alcohol dependence (2011)
- The Liver Disease Delivery Plan for Wales (2015).
- Lancet Commission: Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis (2014)
- Lancet Commission: Implementation of the Lancet Standing Commission on Liver Disease in the UK (2015)
- Lancet Commission: New metrics for the Lancet Standing Commission on Liver Disease in the UK (2016)
- Caring for people with liver disease: a competency framework for nursing (revised edition 2015)
- Scottish Medicines Consortium
- WHO Hepatitis C fact sheet
- WHO Hepatitis B fact sheet
- Shooting Up: Infections among people who inject drugs in the UK
- Public Health England guidance and resources for GPs and patients: towards Hepatitis C elimination - patient re-engagement exercise
Audit, read codes and reflection
Recommended Read Codes for primary care
Read Codes for liver disease are suggested for both SystmOne and EMIS/Vision users. Good use of the Read codes will support effective audit.
- Liver investigations [PDF]
- Non-alcohol-related fatty liver disease [PDF]
- Alcohol-related liver disease [PDF]
- Other liver disease diagnoses [PDF]
- Viral hepatitis [PDF]
Review your practice - Ideas for audit and reflection?
These links contain ideas and suggestions to help you reflect on your clinical practice relating to liver disease. Are you equipped to identify patients with risk factors for liver disease and to help them reduce their risk? Are you equipped to identify and manage early liver disease?
- Practice checklist are all the right things in place for you to prevent and manage liver disease[DOC]
- Clinical audit ideas: identification and management of NAFLD [DOC]
- Clinical audit ideas: identifying and managing cirrhosis in primary care [DOC]
- Clinical audit ideas: reducing the risk of liver disease in those with high alcohol consumption[DOC]
- Clinical audit ideas: managing hepatitis C in primary care [DOC]
- Clinical audit ideas: managing hepatitis B in primary care [DOC]
- Personal reflections: managing neonatal jaundice [DOC]
Liver disease articles and resources
This section contains articles and resources for primary care practitioners on liver disease, its impact, its risk factors and prevention, its early diagnosis and its management.
- Liver disease in the UK, an overview [PDF]
- Cirrhosis and its management in primary care [PDF]
- Non-alcohol-related fatty liver disease and its management [PDF]
- Alcohol-related liver disease and its management [PDF]
- Hepatitis B infection [PDF]
- Hepatitis C infection [PDF]
- PHE Patient re-engagement exercise for those who have been diagnosed with hepatitis C [PDF]
- Prolonged neonatal jaundice and its management [PDF]
- LFT blood testing and investigations in liver disease (summarising the British Society of Gastroenterology guidelines 2017) [PDF]
- Getting the most out of Liver Blood Tests [PDF]RCGP Annual Conference & Exhibition session slides
Resources are currently being developed for the following areas:
- Hepatocellular carcinoma
- End of life care in liver disease
- Care after a transplant
- Other viral hepatitis: A D and E
- Hepatic encephalopathy
- Hepatitis A and B immunisation
- Other liver diseases (including autoimmune and metabolic diseases)
Resources for practices and practice nurses
Patient leaflets on different liver conditions
The British Liver Trust has a full range of leaflets on the whole range of liver diseases that can be downloaded for free. The full range of leaflets can be downloaded for free here or your patient can order a free hard copy by calling 01425 481320.The most popular leaflets include:
- Living with Liver disease
- Diet and Liver disease
- Alcohol and liver disease
- Non- alcohol related liver disease
- Different types of liver disease
Liver disease often has no symptoms in the early stages. The British Liver Trust has developed a range of materials covering the risk factors for liver disease and the signs and symptoms of liver disease. They are free to order and include posters and leaflets for display in GP surgeries
Organisations to support you and your patients
This section provides links to a range of organisations that work to prevent liver disease, to support those with liver disease, or provide resources and guidance to practitioners working with patients with liver disease.
British Liver Trust. The British Liver Trust is the leading UK liver disease charity, providing information and support for professionals, patients and carers; promoting prevention and early diagnosis of liver disease; funding and championing research; and campaigning for better services. In addition the Trust has an anonymous love your liver health screener that assesses the risks posed by alcohol, obesity and viral hepatitis and provides a print out of what you need to do and if need be what to discuss with your GP.
Children's Liver Disease Foundation. The CLDF is a UK-wide charity that provides support, information research funds and a voice for all those affected by childhood liver disease.
Yellow Alert. Yellow alert is CLDF's prolonged jaundice in newborn babies awareness campaign. Yellow Alert promotes the early diagnosis and appropriate referral for liver disease in newly born infants.
Alcohol Concern. Alcohol Concern's aims are to help people concerned about their drinking by providing information and guidance, and to help professionals through training, projects and research.
Drinkline. Drinkline provides a national helpline to offer help and signposting for callers worried about their drinking, support for the family and friends of people who are drinking and links to information and self-help materials.
Alcohol Health Alliance. The Alcohol Health Alliance brings together more than 40 organisations that have a shared interest in reducing the damage caused to health by alcohol. Members include medical royal colleges, charities, patient representatives and alcohol health campaigners. Its aims are to highlight the rising levels of alcohol-related harm; propose evidence-based solutions to address the harms; and encourage decision makers to take positive action.
Obesity Health Alliance. The Obesity Health Alliance is a coalition of over 30 organisations who have joined together to fight obesity. Members include medical royal colleges, charities, campaigners and professional associations. The alliance works together to influence Government policy on overweight and obesity.
Hepatitis C Trust. The Hepatitis C Trust is a national UK charity supporting those with hepatitis C infection. It is a patient-led and patient-run organisation and most of its board, staff, and volunteers either have hepatitis C or have had it and have cleared it after treatment.
Hepatitis B positive. This organisation provides information for the public on hepatitis B infection.
Hepatitis Scotland. Hepatitis Scotland provides training for non-statutory organisations, information and support for patient involvement for those with hepatitis B or C infection in Scotland, and resources for health professionals.
British Association for the Study of the Liver. BASL is a multidisciplinary association with 850 members from medical, nursing and research backgrounds. It aims to advance knowledge about liver biology and pathology; disseminate research findings and promote clinical care of liver disease.
British Society of Gastroenterology. The British Society of Gastroenterology promotes the practice and study of gastroenterology within the United Kingdom. It has over three thousand members including physicians, surgeons, pathologists, radiologists, scientists, nurses, dietitians, and others interested in the field. Internationally it is represented at World and European level.
PSC Support is the leading UK-based organisation for anyone affected by Primary Sclerosing Cholangitis (PSC). They offer advice for patients, family members, healthcare providers and researchers. The Primary Sclerosing Cholangitis Online Support Group is a group consisting of people with PSG and provides mutual support
Primary Care Society for Gastroenterology. The PCSG supports the practice of gastroenterology within primary care through providing guidelines, supporting research and educational events. Membership is free.
The RCGP is the professional membership body for family doctors in the UK and overseas. It is committed to improving patient care, clinical standards and GP training and offers resources for GPs in practice including CPD targeted towards liver disease.
Liver disease information for patients and carers
If you have a liver problem yourself, or you are a health professional and one of your patients is worried about developing liver disease, has had an abnormal liver function test, has been diagnosed or is caring for a loved one with a liver condition or has questions about liver cancer, you will need access to jargon-free, patient-friendly, reliable information that has been checked by experts.
This section of the toolkit provides signposts to these resources. Much of the information is detailed and will useful for health care professionals as well as patients.
General Information
The British Liver Trust has a free patient helpline run by nurses with liver disease expertise.
Helpline: 0800 652 7330 (10am to 3pm Monday to Friday)
Liver Cancer Information
- British Liver Trust on liver cancer
- Liver Cancer leaflet free download
- Cancer Research UK Liver cancer
- Macmillan Cancer Support Liver cancer
Hepatitis C Trust
The Hepatitis C Trust produces a range of materials and run a helpline on 0845 223 4424 or 020 7089 6221(10.30am to 4.30pm Monday to Friday). Alternatively, you can email helpline@hepctrust.org.uk
Patient leaflets on different liver conditions
The British Liver Trust has a full range of leaflets on the whole range of liver diseases that can be downloaded for free. The full range of leaflets can be downloaded for free here or your patient can order a free hard copy by calling 01425 481320.The most popular leaflets include:
- Public Health England information Hepatitis C and your liver
- Public Health England information on Hepatitis C for patients
- Living with Liver disease
- Diet and Liver disease
- Alcohol and liver disease
- Non- alcohol related liver disease
- Different types of liver disease
Liver disease often has no symptoms in the early stages. The British Liver Trust has developed a range of materials covering the risk factors for liver disease and the signs and symptoms of liver disease. They are free to order and include posters and leaflets for display in GP surgeries
Children's Liver diseases
The Children's Liver Disease Foundation has a range of support information and offers support on the different types of liver disease affecting children.
There are also local support groups and support groups for rarer types of liver disease
Innovation and best practice in primary care
Many local teams have led innovative and exciting developments in the prevention and management of liver disease in their areas across the UK, some of these are listed below.
If you've been involved in innovative or best practice in the management of liver disease and you would like to share details of your project, please complete the pro forma and email it to circ@rcgp.org.uk
The Bolton Alcohol Project
Teams in Bolton have developed integrated and collaborative changes that led to:
- the creation of a consultant-led hospital based alcohol care team that has improved the care and reduced admissions for alcohol-related conditions
- a primary care project that has been highly successful in identifying alcohol problems through screening with the AUDIT-C test and signposting patients to early interventions
Liver health screening in Middlesbrough
Middlesbrough has developed a 'Live Well Centre'. The centre is a one-stop shop to support people in changing their lives for the better across a full spectrum of life issues. The project is specifically building in the identification of risk factors for liver disease together with signposting to further interventions as part of an opportunistic screening programme.
End of life care for patients with advanced liver disease
St Luke's Hospice, Basildon, has worked collaboratively with local secondary care hepatology services to create a Shared Care Liver Project designed to meet the unmet needs of patients with advanced liver disease and to improve end of life care.
The Scarred Liver Project Nottingham
The Scarred Liver Project has developed an effective community-based diagnostic pathway for identifying liver disease which stratifies patients using validated non-invasive tests. GPs can refer patients with a defined risk factor for chronic liver disease directly for transient elastography (Fibroscan) before considering referral to secondary care. The aims of the project include improving the early detection of liver disease and providing brief lifestyle interventions for those attending for screening.
The St Mary's Surgery Liver Project Southampton
The St Mary's Surgery Southampton recognised that the patients in their large inner city practice were likely to have a high prevalence of liver disease. Having been part of the ‘Locate’ project the practice worked with local liver specialists to improve their identification and management of liver disease through the development of local clinical pathways and through direct GP access to transient elastography (TE).
The West Midlands Liver Health Work
Recognising higher than average liver disease mortality in the region, together with high levels of health inequality, local PHE leads have brought together services and organisations to address the human and financial costs arising from this. Through local workshops and the creation of a local network, the region has put in place strategies to improve the early detection of liver disease and improve the patient experience.
The Liver Matters Project
The 'Liver Matters' project has worked across the Birmingham South Central CCG to enhance the quality of life for people with alcohol related liver disease and their carer(s) and families, providing information and advice, liaising with treatment services, expanding social networks, and supporting end of life care.
The Glasgow Liver Support Service
The Glasgow Ambulatory Liver Support Service was set up with the aim of reducing re-admissions in patients admitted with decompensated cirrhosis by 20%. Focusing on three novel interventions: pre-discharge patient education; post-discharge review; and re-admission prevention strategies; it has been successful in achieving its goals.
Tayside iLFTs
Testing LFTs should be an opportunity to allow early diagnosis, but abnormal LFTs are often incompletely investigated. The Tayside iLFTs project developed an automated investigation algorithm, which maximises diagnosis of liver diseases.
Resources for practices and practice nurses
Patient leaflets on different liver conditions
The British Liver Trust has a full range of leaflets on the whole range of liver diseases that can be downloaded for free. The full range of leaflets can be downloaded for free here or your patient can order a free hard copy by calling 01425 481320.The most popular leaflets include:
- Living with Liver disease
- Diet and Liver disease
- Alcohol and liver disease
- Non- alcohol related liver disease
- Different types of liver disease
Liver disease often has no symptoms in the early stages. The British Liver Trust has developed a range of materials covering the risk factors for liver disease and the signs and symptoms of liver disease. They are free to order and include posters and leaflets for display in GP surgeries
Resources for commissioners
This section provides links to resources specifically aimed at commissioners.
A financial case for action on liver disease has been developed by the Foundation for Liver Research and this report has been endorsed by the lancet commission on liver disease.
Scotland
There is public health information for Scotland relating to:
Wales
There is information on the prevalence of a range of liver diseases in Wales.
England
In England NICE has produced a quality standard for the management of liver disease . This quality standard covers identifying, assessing and managing chronic liver disease in children, young people and adults, and cirrhosis in young people and adults. It describes high-quality care in priority areas for improvement.
NHS England has published a policy statement on the management of chronic Hepatitis C in patients with cirrhosis.
The Foundation for Liver Research has compiled customised liver disease profiles for each of the 533 parliamentary constituencies in England:
- Profiles for constituencies with names beginning a-s
- Profiles for constituencies with names beginning t-z
Public Health England has developed an atlas that shows variation in healthcare for people with liver disease England
Further information
Liver disease in primary care articles
As part of RCGP/British Liver partnership, our Clinical Champion has written a number of articles and also presented at the RCGP main conference. Some of the articles are below:
Detecting liver disease in primary care: are we ready for change?
How can primary care enhance end-of-life care for liver disease?
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